Evaluating Sarilumab for Adults with Early Polymyalgia Rheumatica (PMR)
This Phase 4 study is enrolling adults with early polymyalgia rheumatica (PMR) to evaluate sarilumab, a medication that targets inflammation. Participants will receive either sarilumab or a placebo every two weeks while following a gradual, physician-guided reduction of prednisone over 52 weeks. The study is randomized and double-blind, meaning neither participants nor study staff will […]
SPARROW: Blood Sample Collection Study for Immune-Mediated Conditions
The SPARROW study is a multi-center, observational research study currently enrolling participants. It collects blood samples from people with immune-mediated conditions (diseases where the immune system plays a central role, such as rheumatoid arthritis, lupus, or related conditions) to study predictive patterns in the immune system. No experimental treatment is given — participation involves providing […]
Comparing Subcutaneous vs. IV Pegloticase (with Methotrexate) for Uncontrolled Gout
This Phase 3 study is enrolling adults with uncontrolled gout to compare two ways of receiving the medication pegloticase: a subcutaneous injection (under the skin) versus an intravenous (IV) infusion (into a vein). Both groups will also take methotrexate weekly. The study is randomized and double-blind, so neither participants nor study staff will know which […]